2. Signaling Pathways
  3. Anti-infection
  4. Hepatitis E Virus (HEV)

Hepatitis E Virus (HEV)

Hepatitis E Virus

Hepatitis E Virus (HEV) is a non-enveloped, icosahedral virus with a single-stranded positive-sense RNA genome. HEV mainly targets hepatocytes. After entering the body through the oral-fecal route, HEV replicates in the liver. HEV has four genotypes (HEV-1, HEV-2, HEV-3, and HEV-4). HEV-1 and HEV-2 are human-specific genotypes, while HEV-3 and HEV-4 are zoonotic genotypes. In acute infections, HEV can cause symptoms such as jaundice, fever, and abdominal pain. In some cases, especially in pregnant women and immunosuppressed individuals, the infection can be severe and lead to fulminant liver failure or chronic hepatitis[1][2].

Hepatitis E Virus (HEV) Related Products (3):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-178137
    SCR007
    		Inhibitor
    SCR007 is a synthetic carbohydrate receptor (SCR) with broad-spectrum antiviral activity. SCR007 inhibits the entry of enveloped viruses across multiple families (Coronaviridae: SARS-CoV-1, SARS-CoV-2, MERS-CoV; Filoviridae: EBOV, MARV; Paramyxoviridae: NiV, HeV) and the glycosylated nonenveloped rotavirus. SCR007 binds viral envelope N-glycans, blocking viral binding to host cells or both binding and membrane fusion. SCR007 exerts prophylactic effects in hACE2 mice infected with SARS-CoV-2. SCR007 can be used for the study and prevention of enveloped virus pandemics.
    SCR007
  • HY-178135
    SCR005
    		Inhibitor
    SCR005 is a synthetic carbohydrate receptor (SCR) with broad-spectrum antiviral activity. SCR005 inhibits the entry of enveloped viruses across multiple families (Coronaviridae: SARS-CoV-1, SARS-CoV-2, MERS-CoV; Filoviridae: EBOV, MARV; Paramyxoviridae: NiV, HeV) and the glycosylated nonenveloped rotavirus. SCR005 binds viral envelope N-glycans, blocking viral binding to host cells or both binding and membrane fusion. SCR005 exerts prophylactic effects in hACE2 mice infected with SARS-CoV-2. SCR005 can be used for the study and prevention of enveloped virus pandemics.
    SCR005
  • HY-157454
    Antiviral agent 48
    Antiviral agent 48 (compound 9m) is a pan-antiviral agent. Antiviral agent 48 has anti-HEV activity and cytotoxicity (EC90=30.6 nM; CC50=13.8 nM).
    Antiviral agent 48